Anti-UNC93B1 antibody (450-550) (STJ117445)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal UNC93B1 (450-550) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | UNC93B1 |
| Gene ID | 81622 |
| Uniprot ID | UN93B_HUMAN |
| Immunogen Region | 450-550 |
| Immunogen Sequence | KTGLSTLLGILYEDKERQDF IFTIYHWWQAVAIFTVYLGS SLHMKAKLAVLLVTLVAAAV SYLRMEQKLRRGVAPRQPRI PRPQHKVRGYRYLEEDNSDE S |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 450-550 of human UNC93B1 (NP_112192.2). |
Additional Info
| Tissue Specificity | Expressed in plasmocytoid dendritic cells (at protein level). Highly expressed in antigen-presenting cells. Expressed in heart, and at lower level in kidney. Expressed at low level in other tissues. |
| Post Translational Modifications | N-glycosylated. |
| Function | Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B-cells removal. |
| Protein Name | Protein Unc-93 Homolog B1Unc-93b1Hunc93b1 |
| Database Links | Reactome: R-HSA-1679131Reactome: R-HSA-5602415 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinEndosomeLysosomeCytoplasmic VesiclePhagosomeRelocalizes From Endoplasmic Reticulum To Endosome And Lysosome Upon Cell-Stimulation With Cpg DinucleotidesColocalizes With Lamp5 In Large Endosomal Intracellular Vesicles |
| Alternative Antibody Names | Anti-Protein Unc-93 Homolog B1 antibodyAnti-Unc-93b1 antibodyAnti-Hunc93b1 antibodyAnti-UNC93B1 antibodyAnti-UNC93 antibodyAnti-UNC93B antibody |
Information sourced from Uniprot.org