Western blot analysis of various lysates using UNC93B1 Rabbit polyclonal antibody (STJ117445) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 15S.

Anti-UNC93B1 antibody (450-550) (STJ117445)

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STJ117445
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: UNC93B1
Gene ID: 81622
Uniprot ID: UN93B_HUMAN
Immunogen Region: 450-550
Specificity: A synthetic peptide corresponding to a sequence within amino acids 450-550 of human UNC93B1 (NP_112192.2).
Immunogen Sequence: KTGLSTLLGILYEDKERQDF IFTIYHWWQAVAIFTVYLGS SLHMKAKLAVLLVTLVAAAV SYLRMEQKLRRGVAPRQPRI PRPQHKVRGYRYLEEDNSDE S
Tissue Specificity Expressed in plasmocytoid dendritic cells (at protein level). Highly expressed in antigen-presenting cells. Expressed in heart, and at lower level in kidney. Expressed at low level in other tissues.
Post Translational Modifications N-glycosylated.
Function Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B-cells removal.
Protein Name Protein Unc-93 Homolog B1
Unc-93b1
Hunc93b1
Database Links Reactome: R-HSA-1679131
Reactome: R-HSA-5602415
Cellular Localisation Endoplasmic Reticulum Membrane
Multi-Pass Membrane Protein
Endosome
Lysosome
Cytoplasmic Vesicle
Phagosome
Relocalizes From Endoplasmic Reticulum To Endosome And Lysosome Upon Cell-Stimulation With Cpg Dinucleotides
Colocalizes With Lamp5 In Large Endosomal Intracellular Vesicles
Alternative Antibody Names Anti-Protein Unc-93 Homolog B1 antibody
Anti-Unc-93b1 antibody
Anti-Hunc93b1 antibody
Anti-UNC93B1 antibody
Anti-UNC93 antibody
Anti-UNC93B antibody

Information sourced from Uniprot.org

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