| Host: |
Goat |
| Applications: |
Pep-ELISA/IF/IHC |
| Reactivity: |
Human/Mouse/Dog |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-UNC5C (Internal) is suitable for use in ELISA, Immunofluorescence and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
Peptide ELISA: antibody detection limit dilution 1:32000.WB: Preliminary experiments in Human and Mouse Brain lysates gave no specific signal but low background (at antibody concentration up to 1µg/ml).IHC: In paraffin embedded Human Cerebr |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
UNC5C |
| Gene ID: |
8633 |
| Uniprot ID: |
UNC5C_HUMAN |
| Immunogen Region: |
Internal |
| Accession Number: |
NP_003719.2 |
| Immunogen Sequence: |
NCTVSEEPTGID |
| Post Translational Modifications | Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis. Phosphorylated on different cytoplasmic tyrosine residues. Phosphorylation of Tyr-568 leads to an interaction with PTPN11 phosphatase, suggesting that its activity is regulated by phosphorylation/dephosphorylation. Tyrosine phosphorylation is netrin-dependent. |
| Function | Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. NTN1/Netrin-1 binding might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Axon repulsion in growth cones may also be caused by its association with DCC that may trigger signaling for repulsion. Might also collaborate with DSCAM in NTN1-mediated axon repulsion independently of DCC. Also involved in corticospinal tract axon guidance independently of DCC. Involved in dorsal root ganglion axon projection towards the spinal cord. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. |
| Protein Name | Netrin Receptor Unc5cProtein Unc-5 Homolog 3Protein Unc-5 Homolog C |
| Database Links | Reactome: R-HSA-418886 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell SurfaceSynapseSynaptosomeCell ProjectionAxonDendriteGrowth ConeLamellipodiumFilopodium |
| Alternative Antibody Names | Anti-Netrin Receptor Unc5c antibodyAnti-Protein Unc-5 Homolog 3 antibodyAnti-Protein Unc-5 Homolog C antibodyAnti-UNC5C antibodyAnti-UNC5H3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
