| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Netrin receptor UNC5A (130-210 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
UNC5A |
| Gene ID: |
90249 |
| Uniprot ID: |
UNC5A_HUMAN |
| Immunogen Region: |
130-210 aa |
| Specificity: |
UNC5A Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from the human protein at the amino acid range 130-210 |
| Function | Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. |
| Protein Name | Netrin Receptor Unc5aProtein Unc-5 Homolog 1Protein Unc-5 Homolog A |
| Database Links | Reactome: R-HSA-373752Reactome: R-HSA-418886Reactome: R-HSA-418889 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinMembrane RaftCell ProjectionNeuron ProjectionThe Interaction With Prkcabp Regulates Its Surface Expression And Leads To Its Removal From The Surface Of Neurons And Growth Cones |
| Alternative Antibody Names | Anti-Netrin Receptor Unc5a antibodyAnti-Protein Unc-5 Homolog 1 antibodyAnti-Protein Unc-5 Homolog A antibodyAnti-UNC5A antibodyAnti-KIAA1976 antibodyAnti-UNC5H1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
