| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Human/Mouse/Rat/Dog |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-UNC45B (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:2000.WB: Approx 90kDa band observed in Human Skeletal Muscle lysates (calculated MW of 104kDa according to NP_775259.1). Recommended concentration: 0.3-1µg/ml. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | UNC45B |
| Gene ID: | 146862 |
| Uniprot ID: | UN45B_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_775259.1; NP_001028748.1 |
| Specificity: | This antibody is expected to recognise both reported isoforms (NP_775259.1and NP_001028748.1). |
| Immunogen Sequence: | RSDKLRQKIFKER |
| Function | Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain. Plays a role in sarcomere formation during muscle cell development. Is necessary for normal early lens development. |
| Protein Name | Protein Unc-45 Homolog BUnc-45bSmunc45 |
| Cellular Localisation | CytoplasmMyofibrilSarcomereZ LineA BandPerinuclear RegionCytosolExpressed At The Z Line And In The Perinuclear Region Of MyofibrilsTranslocates To The A Band In Response To Stress Conditions And Fibril Damage |
| Alternative Antibody Names | Anti-Protein Unc-45 Homolog B antibodyAnti-Unc-45b antibodyAnti-Smunc45 antibodyAnti-UNC45B antibodyAnti-CMYA4 antibodyAnti-UNC45 antibody |
Information sourced from Uniprot.org