| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | UNC13D |
| Gene ID: | 201294 |
| Uniprot ID: | UN13D_HUMAN |
| Immunogen Region: | 891-1090 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 891-1090 of human UNC13D (NP_954712.1). |
| Immunogen Sequence: | LIRKYFCSRIQQQAETTSEE LGAVTVKASYRASEQKLRVE LLSASSLLPLDSNGSSDPFV QLTLEPRHEFPELAARETQK HKKDLHPLFDETFEFLVPAE PCRKAGACLLLTVLDYDTLG ADDLEGEAFLPLREVPGLSG SEEPGEVPQTRLPLTYPAPN GDPILQLLEGRKGDREAQVF VRLRRHRAKQASQHALRPAP |
| Tissue Specificity | Expressed at high levels in spleen, thymus and leukocytes. Also expressed in lung and placenta, and at very low levels in brain, heart, skeletal muscle and kidney. Expressed in cytotoxic T-lymphocytes (CTL) and mast cells. |
| Function | Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. |
| Protein Name | Protein Unc-13 Homolog D Munc13-4 |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Cytoplasm Membrane Peripheral Membrane Protein Late Endosome Recycling Endosome Lysosome Colocalizes With Cytotoxic Granules At The Plasma Membrane Localizes To Endosomal Exocytic Vesicles |
| Alternative Antibody Names | Anti-Protein Unc-13 Homolog D antibody Anti-Munc13-4 antibody Anti-UNC13D antibody |
Information sourced from Uniprot.org