| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | UNC13B |
| Gene ID: | 10497 |
| Uniprot ID: | UN13B_HUMAN |
| Immunogen Region: | 1-350 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human UNC13B (NP_006368.3). |
| Immunogen Sequence: | MSLLCVRVKRAKFQGSPDKF NTYVTLKVQNVKSTTVAVRG DQPSWEQDFMFEISRLDLGL SVEVWNKGLIWDTMVGTVWI ALKTIRQSDEEGPGEWSTLE AETLMKDDEICGTRNPTPHK ILLDTRFELPFDIPEEEARY WTYKWEQINALGADNEYSSQ EESQRKPLPTAAAQCSFEDP DSAVDDRDSDYRSETSNSFP PPYHTASQPNASVHQFPVPV RSPQQLLLQGSSRDSCNDS |
| Tissue Specificity | Expressed in kidney cortical epithelial cells and brain. |
| Function | Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. In collaboration with UNC13A, facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release. |
| Protein Name | Protein Unc-13 Homolog BMunc13-2Munc13 |
| Database Links | Reactome: R-HSA-181429Reactome: R-HSA-181430Reactome: R-HSA-210500Reactome: R-HSA-212676Reactome: R-HSA-264642 |
| Cellular Localisation | CytoplasmMembranePeripheral Membrane ProteinCell MembraneSynapseLocalized To SynapsesTranslocated To The Plasma Membrane In Response To Phorbol Ester Binding |
| Alternative Antibody Names | Anti-Protein Unc-13 Homolog B antibodyAnti-Munc13-2 antibodyAnti-Munc13 antibodyAnti-UNC13B antibodyAnti-UNC13 antibody |
Information sourced from Uniprot.org