Anti-UGT1A1 antibody (36-86 aa) (STJ194234)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human UD11 at the amino acid range 36-86
General Information
| Short Description | Rabbit polyclonal anti-UDP-glucuronosyltransferase 1A1 (36-86 aa) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | UGT1A1 |
| Gene ID | 54658 |
| Uniprot ID | UD11_HUMAN |
| Immunogen | Synthesized peptide derived from the human UD11 at the amino acid range 36-86 |
| Immunogen Region | 36-86 aa |
| Specificity | This antibody detects endogenous levels of UD11 at Human/Mouse/Rat |
Additional Info
| Function | Isoform 1: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol, estrone and estriol. Involved in the glucuronidation of bilirubin, a degradation product occurring in the normal catabolic pathway that breaks down heme in vertebrates. Involved in the glucuronidation of arachidonic acid (AA) and AA-derived eicosanoids including 15-HETE, 20-HETE, PGB1 and F2-isoprostane (8-iso-PGF2alpha). Involved in the glucuronidation of the phytochemical ferulic acid at the phenolic or the carboxylic acid group. Also catalyzes the glucuronidation the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties. Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, a drug which can inhibit the effect of angiotensin II. Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan. Isoform 2: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1. |
| Protein Name | Udp-Glucuronosyltransferase 1a1Ugt1a1Bilirubin-Specific Udpgt Isozyme 1Hug-Br1Udp-Glucuronosyltransferase 1-1Udpgt 1-1Ugt1*1Ugt1-01Ugt1.1Udp-Glucuronosyltransferase 1a Isoform 1 |
| Database Links | Reactome: R-HSA-156588Reactome: R-HSA-189483Reactome: R-HSA-5579002Reactome: R-HSA-9749641Reactome: R-HSA-9753281 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinCytoplasmPerinuclear Region |
| Alternative Antibody Names | Anti-Udp-Glucuronosyltransferase 1a1 antibodyAnti-Ugt1a1 antibodyAnti-Bilirubin-Specific Udpgt Isozyme 1 antibodyAnti-Hug-Br1 antibodyAnti-Udp-Glucuronosyltransferase 1-1 antibodyAnti-Udpgt 1-1 antibodyAnti-Ugt1*1 antibodyAnti-Ugt1-01 antibodyAnti-Ugt1.1 antibodyAnti-Udp-Glucuronosyltransferase 1a Isoform 1 antibodyAnti-UGT1A1 antibodyAnti-GNT1 antibodyAnti-UGT1 antibody |
Information sourced from Uniprot.org