Anti-UFD1 antibody (1-100) [S4143RM] (STJ11104143)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Ubiquitin Recognition Factor In Er-Associated Degradation Protein 1 (1-100) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S4143RM |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | UFD1 |
| Gene ID | 7353 |
| Uniprot ID | UFD1_HUMAN |
| Immunogen Region | 1-100 |
| Immunogen Sequence | MFSFNMFDHPIPRVFQNRFS TQYRCFSVSMLAGPNDRSDV EKGGKIIMPPSALDQLSRLN ITYPMLFKLTNKNSDRMTHC GVLEFVADEGICYLPHWMMQ |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human UFD1L (Q92890). |
Additional Info
| Tissue Specificity | Found in adult heart, skeletal muscle and pancreas, and in fetal liver and kidney. |
| Function | Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures. Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI. |
| Protein Name | Ubiquitin Recognition Factor In Er-Associated Degradation Protein 1Ubiquitin Fusion Degradation Protein 1Ub Fusion Protein 1 |
| Database Links | Reactome: R-HSA-110320Reactome: R-HSA-5689880Reactome: R-HSA-8951664Reactome: R-HSA-9755511 |
| Cellular Localisation | NucleusCytoplasmCytosol |
| Alternative Antibody Names | Anti-Ubiquitin Recognition Factor In Er-Associated Degradation Protein 1 antibodyAnti-Ubiquitin Fusion Degradation Protein 1 antibodyAnti-Ub Fusion Protein 1 antibodyAnti-UFD1 antibodyAnti-UFD1L antibody |
Information sourced from Uniprot.org