![Anti-UCP1 antibody (100-200) [S4630RM] (STJ11104630)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/177274/368909/STJ11104630_1__25191.1713134388.png?c=1 "Anti-UCP1 antibody (100-200) [S4630RM] (STJ11104630)")
![Anti-UCP1 antibody (100-200) [S4630RM] (STJ11104630)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/177274/368909/STJ11104630_1__25191.1713134388.png?c=1 "Anti-UCP1 antibody (100-200) [S4630RM] (STJ11104630)")
| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S4630RM |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:6000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | UCP1 |
| Gene ID: | 7350 |
| Uniprot ID: | UCP1_HUMAN |
| Immunogen Region: | 100-200 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human UCP1 (NP_068605.1). |
| Immunogen Sequence: | QEFLTAGKETAPSLGSKILA GLTTGGVAVFIGQPTEVVKV RLQAQSHLHGIKPRYTGTYN AYRIIATTEGLTGLWKGTTP NLMRSVIINCTELVTYDLMK E |
| Tissue Specificity | Brown adipose tissue. |
| Post Translational Modifications | May undergo sulfenylation upon cold exposure. May increase the sensitivity of UCP1 thermogenic function to the activation by noradrenaline probably through structural effects. May undergo ubiquitin-mediated proteasomal degradation. |
| Function | Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria. |
| Protein Name | Mitochondrial Brown Fat Uncoupling Protein 1 Ucp 1 Solute Carrier Family 25 Member 7 Thermogenin |
| Database Links | Reactome: R-HSA-166187 Reactome: R-HSA-167826 Reactome: R-HSA-9844594 |
| Cellular Localisation | Mitochondrion Inner Membrane Multi-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Mitochondrial Brown Fat Uncoupling Protein 1 antibody Anti-Ucp 1 antibody Anti-Solute Carrier Family 25 Member 7 antibody Anti-Thermogenin antibody Anti-UCP1 antibody Anti-SLC25A7 antibody Anti-UCP antibody |
Information sourced from Uniprot.org