| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
UBXN6 |
| Gene ID: |
80700 |
| Uniprot ID: |
UBXN6_HUMAN |
| Immunogen Region: |
49-388 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 49-388 of human UBXN6 (NP_001164562.1). |
| Immunogen Sequence: |
TNVVSEPREEGSAHLAVPGV YFTCPLTGATLRKDQRDACI KEAILLHFSTDPVAASIMKI YTFNKDQDRVKLGVDTIAKY LDNIHLHPEEEKYRKIKLQN KVFQERINCLEGTHEFFEAI GFQKVLLPAQDQEDPEEFYV LSETTLAQPQSLERHKEQLL AAEPVRAKLDRQRRVFQPSP LASQFELPGDFFNLTAEEIK REQRLRSEAVERLSVLRTKA MREKEEQRGLRKYNYTLLR |
| Tissue Specificity | Enhanced expression in testis. |
| Function | May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes. As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation. It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. |
| Protein Name | Ubx Domain-Containing Protein 6Ubx Domain-Containing Protein 1 |
| Cellular Localisation | CytoplasmCytosolMembranePeripheral Membrane ProteinNucleusCytoskeletonMicrotubule Organizing CenterCentrosomeEarly Endosome MembraneLate Endosome MembraneLysosome MembraneLocalizes At The Centrosome Both In Interphase And During MitosisMay Be Recruited To Endosomal And Lysosomal Membranes As Part Of A Ternary Complex With Cav1 And VcpRecruited To Damaged Lysosomes Decorated With K48-Linked Ubiquitin Chains |
| Alternative Antibody Names | Anti-Ubx Domain-Containing Protein 6 antibodyAnti-Ubx Domain-Containing Protein 1 antibodyAnti-UBXN6 antibodyAnti-UBXD1 antibodyAnti-UBXDC2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
