| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | UBTF |
| Gene ID: | 7343 |
| Uniprot ID: | UBF1_HUMAN |
| Immunogen Region: | 200-440 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 200-440 of human UBTF (NP_055048.1). |
| Immunogen Sequence: | KTPQQLWYTHEKKVYLKVRP DATTKEVKDSLGKQWSQLSD KKRLKWIHKALEQRKEYEEI MRDYIQKHPELNISEEGITK STLTKAERQLKDKFDGRPTK PPPNSYSLYCAELMANMKDV PSTERMVLCSQQWKLLSQKE KDAYHKKCDQKKKDYEVELL RFLESLPEEEQQRVLGEEKM LNINKKQATSPASKKPAQEG GKGGSEKPKRPVSAMFIFSE EKRRQLQEERPELSESELT |
| Post Translational Modifications | Phosphorylated and activated by PIK3CA. |
| Function | Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I (Pol I) through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element and can activate Pol I promoter escape. |
| Protein Name | Nucleolar Transcription Factor 1Autoantigen Nor-90Upstream-Binding Factor 1Ubf-1 |
| Database Links | Reactome: R-HSA-427413Reactome: R-HSA-73728Reactome: R-HSA-73762Reactome: R-HSA-73772Reactome: R-HSA-73863 |
| Cellular Localisation | NucleusNucleolus |
| Alternative Antibody Names | Anti-Nucleolar Transcription Factor 1 antibodyAnti-Autoantigen Nor-90 antibodyAnti-Upstream-Binding Factor 1 antibodyAnti-Ubf-1 antibodyAnti-UBTF antibodyAnti-UBF antibodyAnti-UBF1 antibody |
Information sourced from Uniprot.org