| Host: | Goat |
| Applications: | Pep-ELISA/IHC |
| Reactivity: | Human/Mouse/Rat/Dog |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-UBP1 (Internal) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:2000.WB: Preliminary experiments in Human Kidney, Human Adrenal gland, HeLa and HepG2 lysates gave no specific signal but low background (at antibody concentration up to 2µg/ml).IHC: Paraff |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | UBP1 |
| Gene ID: | 7342 |
| Uniprot ID: | UBIP1_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_055332.3; NP_001121632.1 |
| Specificity: | Reported variants represent identical protein: NP_001121633.1, NP_055332.3. |
| Immunogen Sequence: | PNHQGDGASQTSGE |
| Function | Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2. Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box. |
| Protein Name | Upstream-Binding Protein 1Transcription Factor Lbp-1 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Upstream-Binding Protein 1 antibodyAnti-Transcription Factor Lbp-1 antibodyAnti-UBP1 antibodyAnti-LBP1 antibody |
Information sourced from Uniprot.org