Anti-UBN1 antibody [UBN1-02] (STJ16103407)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant protein corresponding to amino acids 1-190 of ubinuclein 1.
General Information
| Short Description | Mouse monoclonal anti-UBN1 for use in IP and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IP/WB |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | UBN1-02 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by protein-A affinity chromatography. |
| Formulation | Phosphate buffered saline (PBS) , pH 7.4, 15 mM sodium azide |
| Storage Instruction | Store at 2-8°C for up to 1-year, upon receipt. |
Target Information
| Gene Symbol | UBN1 |
| Gene ID | 29855 |
| Uniprot ID | UBN1_HUMAN |
| Immunogen | Recombinant protein corresponding to amino acids 1-190 of ubinuclein 1. |
Additional Info
| Function | Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly. |
| Protein Name | Ubinuclein-1Hira-Binding ProteinProtein Vt4Ubiquitously Expressed Nuclear Protein |
| Database Links | Reactome: R-HSA-2559584 |
| Cellular Localisation | NucleusNucleoplasmPml BodyCell JunctionTight JunctionLocalized As A Nuclear Speckled-Like Pattern In Proliferating Primary FibroblastsColocalizes With HiraPml And Sp100 In Pml Bodies Of Senescent CellsColocalizes With Tjp1 And Cldn1Detected Along The Upper Granular Cell Layer Of EpidermisWhen OverexpressedAccumulates In The Nucleus In Cells Showing Defective Cytokinesis |
| Alternative Antibody Names | Anti-Ubinuclein-1 antibodyAnti-Hira-Binding Protein antibodyAnti-Protein Vt4 antibodyAnti-Ubiquitously Expressed Nuclear Protein antibodyAnti-UBN1 antibody |
Information sourced from Uniprot.org