| Post Translational Modifications | Autoubiquitinated.promoting its own degradation. |
| Function | E3 ubiquitin-protein ligase that specifically catalyzes 'Lys-29'- and 'Lys-48'-linked polyubiquitin chains. Accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Associates with the proteasome and promotes elongation of ubiquitin chains on substrates bound to the 26S proteasome. Also catalyzes 'Lys-29'- and 'Lys-48'-linked ubiquitination of 26S proteasome subunit ADRM1/RPN13 in response to proteotoxic stress, impairing the ability of the proteasome to bind and degrade ubiquitin-conjugated proteins. Acts as a negative regulator of autophagy by mediating 'Lys-29'- and 'Lys-48'-linked ubiquitination of PIK3C3/VPS34, promoting its degradation. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains.with some preference for 'Lys-48' linkages. Acts as a negative regulator of type I interferon by mediating 'Lys-48'-linked ubiquitination of IRF3 and IRF7, leading to their degradation by the proteasome. Catalyzes ubiquitination and degradation of CAND2. |
| Protein Name | Ubiquitin-Protein Ligase E3cHect-Type Ubiquitin Transferase E3cHomologous To E6ap Carboxyl Terminus Homologous Protein 2Hecth2Rta-Associated Ubiquitin LigaseRaul |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Ubiquitin-Protein Ligase E3c antibodyAnti-Hect-Type Ubiquitin Transferase E3c antibodyAnti-Homologous To E6ap Carboxyl Terminus Homologous Protein 2 antibodyAnti-Hecth2 antibodyAnti-Rta-Associated Ubiquitin Ligase antibodyAnti-Raul antibodyAnti-UBE3C antibodyAnti-KIAA0010 antibodyAnti-KIAA10 antibody |
Information sourced from Uniprot.org
