| Host: |
Rabbit |
| Applications: |
WB/IF/ICC/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000IF/ICC:1:10-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
UBE3C |
| Gene ID: |
9690 |
| Uniprot ID: |
UBE3C_HUMAN |
| Immunogen Region: |
970-1083 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 970-1083 of human UBE3C (NP_055486.2). |
| Immunogen Sequence: |
PISLEDLKSFTNYSGGYSAD HPVIKVFWRVVEGFTDEEKR KLLKFVTSCSRPPLLGFKEL YPAFCIHNGGSDLERLPTAS TCMNLLKLPEFYDETLLRSK LLYAIECAAGFELS |
| Tissue Specificity | Highly expressed in skeletal muscle. Detected at much lower levels in kidney and pancreas. |
| Post Translational Modifications | Autoubiquitinated.promoting its own degradation. |
| Function | E3 ubiquitin-protein ligase that specifically catalyzes 'Lys-29'- and 'Lys-48'-linked polyubiquitin chains. Accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Associates with the proteasome and promotes elongation of ubiquitin chains on substrates bound to the 26S proteasome. Also catalyzes 'Lys-29'- and 'Lys-48'-linked ubiquitination of 26S proteasome subunit ADRM1/RPN13 in response to proteotoxic stress, impairing the ability of the proteasome to bind and degrade ubiquitin-conjugated proteins. Acts as a negative regulator of autophagy by mediating 'Lys-29'- and 'Lys-48'-linked ubiquitination of PIK3C3/VPS34, promoting its degradation. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains.with some preference for 'Lys-48' linkages. Acts as a negative regulator of type I interferon by mediating 'Lys-48'-linked ubiquitination of IRF3 and IRF7, leading to their degradation by the proteasome. Catalyzes ubiquitination and degradation of CAND2. |
| Protein Name | Ubiquitin-Protein Ligase E3cHect-Type Ubiquitin Transferase E3cHomologous To E6ap Carboxyl Terminus Homologous Protein 2Hecth2Rta-Associated Ubiquitin LigaseRaul |
| Database Links | Reactome: R-HSA-983168 |
| Alternative Antibody Names | Anti-Ubiquitin-Protein Ligase E3c antibodyAnti-Hect-Type Ubiquitin Transferase E3c antibodyAnti-Homologous To E6ap Carboxyl Terminus Homologous Protein 2 antibodyAnti-Hecth2 antibodyAnti-Rta-Associated Ubiquitin Ligase antibodyAnti-Raul antibodyAnti-UBE3C antibodyAnti-KIAA0010 antibodyAnti-KIAA10 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
