| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-UBE2T (1-197) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
UBE2T |
| Gene ID: |
29089 |
| Uniprot ID: |
UBE2T_HUMAN |
| Immunogen Region: |
1-197 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-197 of human UBE2T (NP_054895.1). |
| Immunogen Sequence: |
MQRASRLKRELHMLATEPPP GITCWQDKDQMDDLRAQILG GANTPYEKGVFKLEVIIPER YPFEPPQIRFLTPIYHPNID SAGRICLDVLKLPPKGAWRP SLNIATVLTSIQLLMSEPNP DDPLMADISSEFKYNKPAFL KNARQWTEKHARQKQKADEE EMLDNLPEAGDSRVHNSTQK RKASQLVGIEKKFHPDV |
| Post Translational Modifications | Auto-ubiquitinated. Effects of auto-monoubiquitination at Lys-91 and Lys-182 are unclear: according to a report, monoubiquitination inactivates E2 enzyme activity. In contrast, according to another report, autoubiquitination does not affect E2 enzyme activity. |
| Function | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair. Acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination. |
| Protein Name | Ubiquitin-Conjugating Enzyme E2 TCell Proliferation-Inducing Gene 50 ProteinE2 Ubiquitin-Conjugating Enzyme TUbiquitin Carrier Protein TUbiquitin-Protein Ligase T |
| Database Links | Reactome: R-HSA-6783310Reactome: R-HSA-8866652 |
| Cellular Localisation | NucleusAccumulates To Chromatin |
| Alternative Antibody Names | Anti-Ubiquitin-Conjugating Enzyme E2 T antibodyAnti-Cell Proliferation-Inducing Gene 50 Protein antibodyAnti-E2 Ubiquitin-Conjugating Enzyme T antibodyAnti-Ubiquitin Carrier Protein T antibodyAnti-Ubiquitin-Protein Ligase T antibodyAnti-UBE2T antibodyAnti-HSPC150 antibodyAnti-PIG50 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
