| Function | Non-catalytic component of the KPC complex, a E3 ubiquitin-protein ligase complex that mediates polyubiquitination of target proteins, such as CDKN1B and NFKB1. The KPC complex catalyzes polyubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle. The KPC complex also acts as a key regulator of the NF-kappa-B signaling by promoting maturation of the NFKB1 component of NF-kappa-B by catalyzing ubiquitination of the NFKB1 p105 precursor. Within the KPC complex, UBAC1 acts as an adapter that promotes the transfer of target proteins that have been polyubiquitinated by RNF123/KPC1 to the 26S proteasome. |
| Protein Name | Ubiquitin-Associated Domain-Containing Protein 1Uba Domain-Containing Protein 1Glialblastoma Cell Differentiation-Related Protein 1Kip1 Ubiquitination-Promoting Complex Protein 2 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Ubiquitin-Associated Domain-Containing Protein 1 antibodyAnti-Uba Domain-Containing Protein 1 antibodyAnti-Glialblastoma Cell Differentiation-Related Protein 1 antibodyAnti-Kip1 Ubiquitination-Promoting Complex Protein 2 antibodyAnti-UBAC1 antibodyAnti-GBDR1 antibodyAnti-KPC2 antibodyAnti-UBADC1 antibody |
Information sourced from Uniprot.org
