| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-U-PAR/CD87 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Approx 60kDa band observed in lysates of cell line U251 (calculated MW of 37.0kDa according to NP_002650.1). The observed molecular weight corresponds to the glycosylated form. Recomm |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | PLAUR |
| Gene ID: | 5329 |
| Uniprot ID: | UPAR_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_002650.1; NP_001005376.1; NP_001005377.1 |
| Specificity: | This antibody is expected to recognize all reported isoforms (NP_002650.1; NP_001005376.1; NP_001005377.1). |
| Immunogen Sequence: | RTGLKITSLTE |
| Function | Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. |
| Protein Name | Urokinase Plasminogen Activator Surface ReceptorU-ParUparMonocyte Activation Antigen Mo3Cd Antigen Cd87 |
| Database Links | Reactome: R-HSA-162791Reactome: R-HSA-6798695Reactome: R-HSA-75205 |
| Cellular Localisation | Cell MembraneCell ProjectionInvadopodium MembraneColocalized With Fap (Seprase) Preferentially At The Cell Surface Of Invadopodia Membrane In A Cytoskeleton-Integrin- And Vitronectin-Dependent MannerIsoform 1: Cell MembraneLipid-AnchorGpi-AnchorIsoform 2: Secreted |
| Alternative Antibody Names | Anti-Urokinase Plasminogen Activator Surface Receptor antibodyAnti-U-Par antibodyAnti-Upar antibodyAnti-Monocyte Activation Antigen Mo3 antibodyAnti-Cd Antigen Cd87 antibodyAnti-PLAUR antibodyAnti-MO3 antibodyAnti-UPAR antibody |
Information sourced from Uniprot.org