| Host: | Rabbit |
| Applications: | IHC-F |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal anti-Tyrosine Kinase Receptor C for use in IHC-F in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | Mixed |
| Purification: | Whole serum |
| Dilution Range: | IHC 1:1000-1:3000 |
| Storage Instruction: | Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at-20°C for a higher stability, and at 2-8°C with an appropriate antibacterial |
| Gene Symbol: | NTRK3 |
| Gene ID: | 4916 |
| Uniprot ID: | NTRK3_HUMAN |
| Specificity: | Specificity was demonstrated by immunohistochemistry. This antibody was used to stain cryostat sections of the rat peripheral sensory ganglia. Reacts with human, rat and mouse TrkC. Other species have not yet been tested. |
| Immunogen: | Extracellular domain of glycosylated human TrkC protein produced in CHO cells was used as the immunogen. |
| Immunogen Sequence: | Human |
| Tissue Specificity | Widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain than in fetal brain. |
| Post Translational Modifications | Ligand-mediated auto-phosphorylation. |
| Function | Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. |
| Protein Name | Nt-3 Growth Factor ReceptorGp145-TrkcTrk-CNeurotrophic Tyrosine Kinase Receptor Type 3Trkc Tyrosine Kinase |
| Database Links | Reactome: R-HSA-1257604Reactome: R-HSA-2219530Reactome: R-HSA-388844Reactome: R-HSA-6811558Reactome: R-HSA-9034013Reactome: R-HSA-9034015Reactome: R-HSA-9034793Reactome: R-HSA-9034864Reactome: R-HSA-9603381Reactome: R-HSA-9603505 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Nt-3 Growth Factor Receptor antibodyAnti-Gp145-Trkc antibodyAnti-Trk-C antibodyAnti-Neurotrophic Tyrosine Kinase Receptor Type 3 antibodyAnti-Trkc Tyrosine Kinase antibodyAnti-NTRK3 antibodyAnti-TRKC antibody |
Information sourced from Uniprot.org