![Anti-Tyrosinase antibody [T311] (STJ16100435)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/149152/346771/STJ16100435_1__22810.1681998870.jpg?c=1 "Anti-Tyrosinase antibody [T311] (STJ16100435)")
![Anti-Tyrosinase antibody [T311] (STJ16100435)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/149152/346771/STJ16100435_1__22810.1681998870.jpg?c=1 "Anti-Tyrosinase antibody [T311] (STJ16100435)")
Anti-Tyrosinase antibody [T311] (STJ16100435)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2a
General Information
| Short Description | Mouse monoclonal anti-Tyrosinase for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | T311 |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Dilution Range | IHC 1:100 – 1:500 |
| Formulation | Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide |
| Storage Instruction | Store at 2-8°C for up to 1-year, upon receipt. |
Target Information
| Gene Symbol | TYR |
| Gene ID | 7299 |
| Uniprot ID | TYRO_HUMAN |
Additional Info
| Post Translational Modifications | Glycosylated. |
| Function | This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. |
| Protein Name | TyrosinaseLb24-AbMonophenol MonooxygenaseSk29-AbTumor Rejection Antigen Ab |
| Database Links | Reactome: R-HSA-5662702Reactome: R-HSA-9824585 |
| Cellular Localisation | Melanosome MembraneSingle-Pass Type I Membrane ProteinMelanosomeProper Trafficking To Melanosome Is Regulated By Sgsm2Ankrd27Rab9aRab32 And Rab38 |
| Alternative Antibody Names | Anti-Tyrosinase antibodyAnti-Lb24-Ab antibodyAnti-Monophenol Monooxygenase antibodyAnti-Sk29-Ab antibodyAnti-Tumor Rejection Antigen Ab antibodyAnti-TYR antibody |
Information sourced from Uniprot.org