Anti-TXNIP antibody (291-391 aa) (STJ11105302)

Name: Anti-TXNIP antibody (291-391 aa) (STJ11105302)
SKU: STJ11105302
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⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ11105302

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Short Description	Rabbit polyclonal Thioredoxin-Interacting Protein (291-391 aa) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/ELISA
Host	Rabbit
Reactivity	Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:1000-1:5000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.09% Sodium Azide, 50% Glycerol, pH7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	TXNIP
Gene ID	10628
Uniprot ID	TXNIP_HUMAN
Immunogen Region	291-391 aa
Immunogen Sequence	DLPLVIGSRSGLSSRTSSMA SRTSSEMSWVDLNIPDTPEA PPCYMDVIPEDHRLESPTTP LLDDMDGSQDSPIFMYAPEF KFMPPPTYTEVDPCILNNNV Q
Specificity	A synthetic peptide corresponding to a sequence within amino acids 291-391 of human TXNIP. (NP_006463.3).

Post Translational Modifications	Ubiquitinated.undergoes heterotypic 'Lys-48'-/'Lys-63'-branched polyubiquitination catalyzed by ITCH and UBR5 resulting in proteasomal degradation. Deubiquitinated by USP5, leading to TXNIP stabilization.
Function	May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).
Protein Name	Thioredoxin-Interacting Protein Thioredoxin-Binding Protein 2 Vitamin D3 Up-Regulated Protein 1
Database Links	Reactome: R-HSA-844456 Reactome: R-HSA-9617629 Reactome: R-HSA-9660826 Reactome: R-HSA-9707564
Cellular Localisation	Cytoplasm Nucleus
Alternative Antibody Names	Anti-Thioredoxin-Interacting Protein antibody Anti-Thioredoxin-Binding Protein 2 antibody Anti-Vitamin D3 Up-Regulated Protein 1 antibody Anti-TXNIP antibody Anti-VDUP1 antibody

Information sourced from Uniprot.org