| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Twinkle mtDNA helicase (173-223) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:1000-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TWNK |
| Gene ID: |
56652 |
| Uniprot ID: |
PEO1_HUMAN |
| Immunogen Region: |
173-223 |
| Specificity: |
This antibody detects endogenous levels of human PEO1 |
| Immunogen: |
Synthesized peptide derived from human PEO1 AA range: 173-223 |
| Function | Isoform 1: Mitochondrial helicase involved in mtDNA replication and repair. Might have a role in mtDNA repair. Has DNA strand separation activity needed to form a processive replication fork for leading strand synthesis which is catalyzed by the formation of a replisome complex with POLG and mtSDB. Preferentially unwinds DNA substrates with pre-existing 5'-and 3'- single-stranded tails but is also active on a 5'- flap substrate. Can dissociate the invading strand of immobile or mobile D-loop DNA structures irrespective of the single strand polarity of the third strand. In addition to its DNA strand separation activity, also has DNA strand annealing, DNA strand-exchange and DNA branch migration activities. Isoform 2: Lack DNA unwinding and ATP hydrolysis activities. Does not bind single-stranded or double-stranded DNA. |
| Protein Name | Twinkle Mtdna HelicaseProgressive External Ophthalmoplegia 1 ProteinT7 Gp4-Like Protein With Intramitochondrial Nucleoid LocalizationT7-Like Mitochondrial Dna HelicaseTwinkle Protein - Mitochondrial |
| Database Links | Reactome: R-HSA-2151201 |
| Cellular Localisation | Mitochondrion MatrixMitochondrion NucleoidColocalizes With Mtdna In Mitochondrial NucleoidsA Nucleoproteins Complex Consisting Of A Number Of Copies Of Proteins Associated With MtdnaProbably Involved In Mtdna Maintenance And Expression |
| Alternative Antibody Names | Anti-Twinkle Mtdna Helicase antibodyAnti-Progressive External Ophthalmoplegia 1 Protein antibodyAnti-T7 Gp4-Like Protein With Intramitochondrial Nucleoid Localization antibodyAnti-T7-Like Mitochondrial Dna Helicase antibodyAnti-Twinkle Protein - Mitochondrial antibodyAnti-TWNK antibodyAnti-C10orf2 antibodyAnti-PEO1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
