| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Twist (51-150) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TWIST1 |
| Gene ID: |
7291 |
| Uniprot ID: |
TWST1_HUMAN |
| Immunogen Region: |
51-150 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 51-150 of human Twist (NP_000465.1). |
| Immunogen Sequence: |
GPGGAAGGGVGGGDEPGSPA QGKRGKKSAGCGGGGGAGGG GGSSSGGGSPQSYEELQTQR VMANVRERQRTQSLNEAFAA LRKIIPTLPSDKLSKIQTLK |
| Tissue Specificity | Subset of mesodermal cells. |
| Function | Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of pro-inflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-BMAL1 heterodimer. |
| Protein Name | Twist-Related Protein 1Class A Basic Helix-Loop-Helix Protein 38Bhlha38H-Twist |
| Database Links | Reactome: R-HSA-6785807Reactome: R-HSA-8878166Reactome: R-HSA-8939902 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Twist-Related Protein 1 antibodyAnti-Class A Basic Helix-Loop-Helix Protein 38 antibodyAnti-Bhlha38 antibodyAnti-H-Twist antibodyAnti-TWIST1 antibodyAnti-BHLHA38 antibodyAnti-TWIST antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
