Anti-TUFM antibody (186-455) (STJ28506)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal TUFM (186-455) antibody for use in WB, IHC-P, IF, ICC, IP and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/IP/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200IF/ICC:1:10-1:100IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specif |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TUFM |
| Gene ID | 7284 |
| Uniprot ID | EFTU_HUMAN |
| Immunogen Region | 186-455 |
| Immunogen Sequence | ADAVQDSEMVELVELEIREL LTEFGYKGEETPVIVGSALC ALEGRDPELGLKSVQKLLDA VDTYIPVPARDLEKPFLLPV EAVYSVPGRGTVVTGTLERG ILKKGDECELLGHSKNIRTV VTGIEMFHKSLERAEAGDNL GALVRGLKREDLRRGLVMVK PGSIKPHQKVEAQVYILSKE EGGRHKPFVSHFMPVMFSLT WDMACRIILPPEKELAMPGE DLKFNLILRQPMILEKGQR |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 186-455 of human TUFM (NP_003312.3). |
Additional Info
| Function | GTP hydrolase that promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Also plays a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIGI-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy. |
| Protein Name | Elongation Factor Tu - MitochondrialEf-TuP43 |
| Database Links | Reactome: R-HSA-5389840Reactome: R-HSA-9754560 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Elongation Factor Tu - Mitochondrial antibodyAnti-Ef-Tu antibodyAnti-P43 antibodyAnti-TUFM antibody |
Information sourced from Uniprot.org