Anti-TTYH2 nanobody [SAA2300] (STJN000683)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-His
General Information
| Short Description | Alpaca monoclonal nanobody anti-TTYH2 is suitable for use in ELISA research applications. |
| Applications | ELISA |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA2300 |
| Isotype | VHH-His |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Purified by Nickel column. |
| Dilution Range | ELISA: 1:2000-1:20000 |
| Formulation | 0.01M PBS pH 7.4 |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact with the lab for this information. |
Target Information
| Gene Symbol | TTYH2 |
| Gene ID | 94015 |
| Uniprot ID | TTYH2_HUMAN |
Additional Info
| Post Translational Modifications | N- Glycosylated. Contains high-mannose, hybrid and complex oligosaccharides. Ubiquitinated by NEDD4L, leading to its proteasomal degradation. |
| Function | Calcium-independent, swelling-dependent volume-regulated anion channel (VRAC-swell) which plays a pivotal role in the process of regulatory volume decrease (RVD) in the brain through the efflux of anions like chloride and organic osmolytes like glutamate. Probable large-conductance Ca(2+)-activated chloride channel. |
| Protein Name | Protein Tweety Homolog 2Htty2Volume-Regulated Anion Channel Subunit Ttyh2 |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Nanobody Names | Anti-Protein Tweety Homolog 2 nanobodyAnti-Htty2 nanobodyAnti-Volume-Regulated Anion Channel Subunit Ttyh2 nanobodyAnti-TTYH2 nanobodyAnti-C17orf29 nanobody |
Information sourced from Uniprot.org