• Immunohistochemical analysis of paraffin-embedded human tonsil. 1, Antibody was diluted at 1:200 (4°C overnight). 2, Tris-EDTA, pH9.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 45min).

Anti-TTR antibody (81-130) (STJA0010160)

SKU:
STJA0010160

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Transthyretin (81-130) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
IHC-p 1:50-300
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TTR
Gene ID: 7276
Uniprot ID: TTHY_HUMAN
Immunogen Region: 81-130
Specificity: This antibody detects endogenous levels of Human Prealbumin
Immunogen: Synthesized peptide derived from human Prealbumin AA range: 81-130
Tissue Specificity Detected in serum and cerebrospinal fluid (at protein level). Highly expressed in choroid plexus epithelial cells. Detected in retina pigment epithelium and liver.
Post Translational Modifications Not glycosylated under normal conditions. Following unfolding, caused for example by variant AMYL-TTR 'Gly-38', the cryptic Asn-118 site is exposed and glycosylated by STT3B-containing OST complex, leading to its degradation by the ER-associated degradation (ERAD) pathway. Sulfonation of the reactive cysteine Cys-30 enhances the stability of the native conformation of TTR, avoiding misassembly of the protein leading to amyloid formation.
Function Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.
Protein Name Transthyretin
Attr
Prealbumin
Tbpa
Database Links Reactome: R-HSA-2453864
Reactome: R-HSA-2453902
Reactome: R-HSA-3000171
Reactome: R-HSA-6798695
Reactome: R-HSA-975634
Reactome: R-HSA-977225
Cellular Localisation Secreted
Cytoplasm
Alternative Antibody Names Anti-Transthyretin antibody
Anti-Attr antibody
Anti-Prealbumin antibody
Anti-Tbpa antibody
Anti-TTR antibody
Anti-PALB antibody

Information sourced from Uniprot.org

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