Anti-TTLL12 antibody (1-450) (STJ110496)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal TTLL12 (1-450) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TTLL12 |
| Gene ID | 23170 |
| Uniprot ID | TTL12_HUMAN |
| Immunogen Region | 1-450 |
| Immunogen Sequence | MEAERGPERRPAERSSPGQT PEEGAQALAEFAALHGPALR ASGVPERYWGRLLHKLEHEV FDAGEVFGIMQVEEVEEEED EAAREVRKQQPNPGNELCYK VIVTRESGLQAAHPNSIFLI DHAWTCRVEHARQQLQQVPG LLHRMANLMGIEFHGELPST EAVALVLEEMWKFNQTYQLA HGTAEEKMPVWYIMDEFGSR IQHADVPSFATAPFFYMPQQ VAYTLLWPLRDLDTGEEVT |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-450 of human TTLL12 (NP_055955.1). |
Additional Info
| Tissue Specificity | Expressed in the basal layer of prostate and endothelial cells. Increased expression in prostatic intraepithelial neoplasia and metastatic lesions. |
| Function | Negatively regulates post-translational modifications of tubulin, including detyrosination of the C-terminus and polyglutamylation of glutamate residues. Also, indirectly promotes histone H4 trimethylation at 'Lys-20' (H4K20me3). Probably by controlling tubulin and/or histone H4 post-translational modifications, plays a role in mitosis and in maintaining chromosome number stability. During RNA virus-mediated infection, acts as a negative regulator of the RIG-I pathway by preventing MAVS binding to TBK1 and IKBKE. |
| Protein Name | Tubulin--Tyrosine Ligase-Like Protein 12Inactive Tubulin--Tyrosine Ligase-Like Protein 12 |
| Database Links | Reactome: R-HSA-8955332 |
| Cellular Localisation | CytoplasmMidbodyCytoskeletonMicrotubule Organizing CenterCentrosomeSpindleNucleusPredominantly Localizes In The CytoplasmPartially Colocalizes With Vimentin In Prostate Cancer Cells |
| Alternative Antibody Names | Anti-Tubulin--Tyrosine Ligase-Like Protein 12 antibodyAnti-Inactive Tubulin--Tyrosine Ligase-Like Protein 12 antibodyAnti-TTLL12 antibodyAnti-KIAA0153 antibody |
Information sourced from Uniprot.org