Anti-TTLL1 antibody (STJA0004357)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenFusion protein of human TTLL1
General Information
| Short Description | Rabbit polyclonal anti-Polyglutamylase Complex Subunit Ttll1 for use in IHC and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1.56 mg/mL |
| Purification | Antigen affinity purification |
| Dilution Range | IHC 1:50-1:300 |
| Formulation | PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | TTLL1 |
| Gene ID | 25809 |
| Uniprot ID | TTLL1_HUMAN |
| Immunogen | Fusion protein of human TTLL1 |
Additional Info
| Tissue Specificity | Expressed in a wide range of tissues. Has a stronger expression in heart, brain and testis. |
| Function | Catalytic subunit of a polyglutamylase complex which modifies tubulin, generating side chains of glutamate on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin. Probably involved in the side-chain elongation step of the polyglutamylation reaction rather than the initiation step. Modifies both alpha- and beta-tubulins with a preference for the alpha-tail. Unlike most polyglutamylases of the tubulin--tyrosine ligase family, only displays a catalytic activity when in complex with other proteins as it is most likely lacking domains important for autonomous activity. Part of the neuronal tubulin polyglutamylase complex. Mediates cilia and flagella polyglutamylation which is essential for their biogenesis and motility. Involved in respiratory motile cilia function through the regulation of beating asymmetry. Essential for sperm flagella biogenesis, motility and male fertility. Involved in KLF4 glutamylation which impedes its ubiquitination, thereby leading to somatic cell reprogramming, pluripotency maintenance and embryogenesis. |
| Protein Name | Polyglutamylase Complex Subunit Ttll1Tubulin Polyglutamylase Ttll1Tubulin Polyglutamylase Complex Subunit 3Pgs3Tubulin--Tyrosine Ligase-Like Protein 1 |
| Database Links | Reactome: R-HSA-8955332 |
| Cellular Localisation | CytoplasmCytoskeletonCilium Basal BodyCilium AxonemeCell ProjectionCiliumFlagellum |
| Alternative Antibody Names | Anti-Polyglutamylase Complex Subunit Ttll1 antibodyAnti-Tubulin Polyglutamylase Ttll1 antibodyAnti-Tubulin Polyglutamylase Complex Subunit 3 antibodyAnti-Pgs3 antibodyAnti-Tubulin--Tyrosine Ligase-Like Protein 1 antibodyAnti-TTLL1 antibodyAnti-C22orf7 antibody |
Information sourced from Uniprot.org