| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Dual specificity protein kinase TTK (642-691 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TTK |
| Gene ID: | 7272 |
| Uniprot ID: | TTK_HUMAN |
| Immunogen Region: | 642-691 aa |
| Specificity: | TTK Polyclonal Antibody detects endogenous levels of TTK protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human TTK at the amino acid range 642-691 |
| Function | Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments. Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint. Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore. Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments. Phosphorylates KNL1, KNTC1 and autophosphorylates. Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment. |
| Protein Name | Dual Specificity Protein Kinase TtkPhosphotyrosine Picked Threonine-Protein KinasePyt |
| Database Links | |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Dual Specificity Protein Kinase Ttk antibodyAnti-Phosphotyrosine Picked Threonine-Protein Kinase antibodyAnti-Pyt antibodyAnti-TTK antibodyAnti-MPS1 antibodyAnti-MPS1L1 antibody |
Information sourced from Uniprot.org
