Anti-TTK antibody (642-691 aa) (STJ96137)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human TTK at the amino acid range 642-691
General Information
| Short Description | Rabbit polyclonal anti-Dual specificity protein kinase TTK (642-691 aa) for use in WB, IHC, IF and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TTK |
| Gene ID | 7272 |
| Uniprot ID | TTK_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human TTK at the amino acid range 642-691 |
| Immunogen Region | 642-691 aa |
| Specificity | TTK Polyclonal Antibody detects endogenous levels of TTK protein. |
Additional Info
| Function | Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments. Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint. Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore. Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments. Phosphorylates KNL1, KNTC1 and autophosphorylates. Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment. |
| Protein Name | Dual Specificity Protein Kinase TtkPhosphotyrosine Picked Threonine-Protein KinasePyt |
| Database Links | |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Dual Specificity Protein Kinase Ttk antibodyAnti-Phosphotyrosine Picked Threonine-Protein Kinase antibodyAnti-Pyt antibodyAnti-TTK antibodyAnti-MPS1 antibodyAnti-MPS1L1 antibody |
Information sourced from Uniprot.org