• Human lung adenocarcinoma stained with anti-TTF-1 antibody using peroxidase-conjugate and DAB chromogen. Note the nuclear staining of tumor cells.

Anti-TTF-1/NKX2.1 antibody [ZR176] (STJ180546)

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STJ180546

£152.50 - £485.50
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Host: Rabbit
Applications: IHC-P
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-TTF-1/NKX2.1 is suitable for use in Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: ZR176
Conjugation: Unconjugated
Isotype: IgG1/Kappa
Formulation: Tris-HCI buffer containing stabilizing protein (BSA) and <0.1% ProClin
Purification: Affinity purified
Dilution Range: 1:100-200
Storage Instruction: Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C.
Gene Symbol: NKX2-1
Gene ID: 7080
Uniprot ID: NKX21_HUMAN
Specificity: Positive control: Normal thyroid or lung
Immunogen: Recombinant TTF-1 protein
Tissue Specificity Thyroid and lung.
Post Translational Modifications Phosphorylated on serine residues by STK3/MST2.
Function Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1.
Protein Name Homeobox Protein Nkx-2.1
Homeobox Protein Nk-2 Homolog A
Thyroid Nuclear Factor 1
Thyroid Transcription Factor 1
Ttf-1
Thyroid-Specific Enhancer-Binding Protein
T/Ebp
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Homeobox Protein Nkx-2.1 antibody
Anti-Homeobox Protein Nk-2 Homolog A antibody
Anti-Thyroid Nuclear Factor 1 antibody
Anti-Thyroid Transcription Factor 1 antibody
Anti-Ttf-1 antibody
Anti-Thyroid-Specific Enhancer-Binding Protein antibody
Anti-T/Ebp antibody
Anti-NKX2-1 antibody
Anti-NKX2A antibody
Anti-TITF1 antibody
Anti-TTF1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance