Anti-TTC8 antibody (STJA0008891)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human BBS8
General Information
| Short Description | Rabbit polyclonal anti-Tetratricopeptide repeat protein 8 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TTC8 |
| Gene ID | 123016 |
| Uniprot ID | TTC8_HUMAN |
| Immunogen | Synthesized peptide derived from human BBS8 |
| Specificity | This antibody detects endogenous levels of BBS8 at Human, Mouse |
Additional Info
| Function | The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization. |
| Protein Name | Tetratricopeptide Repeat Protein 8Tpr Repeat Protein 8Bardet-Biedl Syndrome 8 Protein |
| Database Links | Reactome: R-HSA-5620922 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCell ProjectionCilium MembraneCentriolar SatelliteCilium |
| Alternative Antibody Names | Anti-Tetratricopeptide Repeat Protein 8 antibodyAnti-Tpr Repeat Protein 8 antibodyAnti-Bardet-Biedl Syndrome 8 Protein antibodyAnti-TTC8 antibodyAnti-BBS8 antibody |
Information sourced from Uniprot.org