| Short Description : | Rabbit monoclonal PBR (70-169) antibody for use in WB, IHC-P, IF, ICC and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S8MR |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:1000-1:6000IHC-P:1:200-1:2000IF/ICC:1:100-1:400ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TSPO |
| Gene ID: | 706 |
| Uniprot ID: | TSPO_HUMAN |
| Immunogen Region: | 70-169 |
| Immunogen Sequence: | ELGGFTEKAVVPLGLYTGQL ALNWAWPPIFFGARQMGWAL VDLLLVSGAAAATTVAWYQV SPLAARLLYPYLAWLAFTTT LNYCVWRDNHGWRGGRRLPE |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 70-169 of human PBR/TSPO (P30536). |
| Tissue Specificity | Found in many tissue types. Expressed at the highest levels under normal conditions in tissues that synthesize steroids. |
| Function | Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme. Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism, but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Was initially identified as peripheral-type benzodiazepine receptor.can also bind isoquinoline carboxamides. |
| Protein Name | Translocator ProteinMitochondrial Benzodiazepine ReceptorPkbsPeripheral-Type Benzodiazepine ReceptorPbr |
| Database Links | Reactome: R-HSA-196108 |
| Cellular Localisation | Mitochondrion MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Translocator Protein antibodyAnti-Mitochondrial Benzodiazepine Receptor antibodyAnti-Pkbs antibodyAnti-Peripheral-Type Benzodiazepine Receptor antibodyAnti-Pbr antibodyAnti-TSPO antibodyAnti-BZRP antibodyAnti-MBR antibody |
Information sourced from Uniprot.org
