| Tissue Specificity | Expressed in multiple tissues but is absent in brain, lymphoid cells, and platelets. |
| Function | Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Plays an essential role in migrasome formation and migration on retracting fibers at the rear end of migrating cells. Migrasomes are cellular organelles that form as large vesicle-like structures on retraction fibers of migrating cells. Mechanistically, acts as a membrane curvature sensor and participates in stabilizing the migrasome structure in a late stage of biogenesis. May also play a regulatory role for the histamine H4 receptor/HRH4 without affecting histamine binding to HRH4 or signaling. |
| Protein Name | Tetraspanin-4Tspan-4Novel Antigen 2Nag-2Transmembrane 4 Superfamily Member 7 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Tetraspanin-4 antibodyAnti-Tspan-4 antibodyAnti-Novel Antigen 2 antibodyAnti-Nag-2 antibodyAnti-Transmembrane 4 Superfamily Member 7 antibodyAnti-TSPAN4 antibodyAnti-NAG2 antibodyAnti-TM4SF7 antibody |
Information sourced from Uniprot.org
