Western blot analysis of lysates from mouse spleen, using TSPAN15 Rabbit polyclonal antibody (STJ116607) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 90s.

Anti-TSPAN15 antibody (110-220) (STJ116607)

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STJ116607
£112.50 - £524.50
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TSPAN15
Gene ID: 23555
Uniprot ID: TSN15_HUMAN
Immunogen Region: 110-220
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 110-220 of human TSPAN15 (NP_036471.1).
Immunogen Sequence: GVVALTFRNQTIDFLNDNIR RGIENYYDDLDFKNIMDFVQ KKFKCCGGEDYRDWSKNQYH DCSAPGPLACGVPYTCCIRN TTEVVNTMCGYKTIDKERFS VQDVIYVRGCT
Post Translational Modifications Palmitoylated.
Function Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates. Promotes ADAM10-mediated cleavage of CDH2. Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity.
Protein Name Tetraspanin-15
Tspan-15
Tetraspan Net-7
Transmembrane 4 Superfamily Member 15
Database Links Reactome: R-HSA-977225
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Late Endosome Membrane
Alternative Antibody Names Anti-Tetraspanin-15 antibody
Anti-Tspan-15 antibody
Anti-Tetraspan Net-7 antibody
Anti-Transmembrane 4 Superfamily Member 15 antibody
Anti-TSPAN15 antibody
Anti-NET7 antibody
Anti-TM4SF15 antibody
Anti-UNQ677 antibody
Anti-PRO1311 antibody

Information sourced from Uniprot.org

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