• Western blot analysis of the lysates from HepG2 cells using TSC22D1 antibody.
  • Immunohistochemistry analysis of paraffin-embedded human brain tissue, using TSC22D1 Antibody. The picture on the right is blocked with the synthesized peptide.
  • Western blot analysis of lysates from mouse liver and rat liver cells, using TSC22D1 Antibody. The lane on the right is blocked with the synthesized peptide.
  • Immunofluorescence analysis of HepG2 cells, using TSC22D1 Antibody. The picture on the right is blocked with the synthesized peptide.

Anti-TSC22D1 antibody (71-120 aa) (STJ96123)

SKU:
STJ96123

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-TSC22 domain family protein 1 (71-120 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TSC22D1
Gene ID: 8848
Uniprot ID: T22D1_HUMAN
Immunogen Region: 71-120 aa
Specificity: TSC-22 Polyclonal Antibody detects endogenous levels of TSC-22 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human TSC22D1 at the amino acid range 71-120
Function Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter. Acts to promote CASP3-mediated apoptosis. Positively regulates TGF-beta signaling by interacting with SMAD7 which inhibits binding of SMAD7 to TGFBR1, preventing recruitment of SMURF ubiquitin ligases to TGFBR1 and inhibiting SMURF-mediated ubiquitination and degradation of TGFBR1. Contributes to enhancement of TGF-beta signaling by binding to and modulating the transcription activator activity of SMAD4. Promotes TGF-beta-induced transcription of COL1A2.via its interaction with TFE3 at E-boxes in the gene proximal promoter. Plays a role in the repression of hematopoietic precursor cell growth. Promotes IL2 deprivation-induced apoptosis in T-lymphocytes, via repression of TSC22D3/GILZ transcription and activation of the caspase cascade. Isoform 1: May act to negatively regulate TGFB3 signaling and thereby inhibit cell death in mammary gland cells. Isoform 2: Positively regulates cell death in response to TGFB3 during mammary gland involution.
Protein Name Tsc22 Domain Family Protein 1
Cerebral Protein 2
Hucep-2
Regulatory Protein Tsc-22
Tgfb-Stimulated Clone 22 Homolog
Transforming Growth Factor Beta-1-Induced Transcript 4 Protein
Cellular Localisation Cytoplasm
Nucleus
Cell Membrane
Peripheral Membrane Protein
Isoform 1: Cytoplasm
Mitochondrion
Isoform 2: Cytoplasm
Isoform 5: Cytoplasm
Alternative Antibody Names Anti-Tsc22 Domain Family Protein 1 antibody
Anti-Cerebral Protein 2 antibody
Anti-Hucep-2 antibody
Anti-Regulatory Protein Tsc-22 antibody
Anti-Tgfb-Stimulated Clone 22 Homolog antibody
Anti-Transforming Growth Factor Beta-1-Induced Transcript 4 Protein antibody
Anti-TSC22D1 antibody
Anti-KIAA1994 antibody
Anti-TGFB1I4 antibody
Anti-TSC22 antibody
Anti-hucep-2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance