Anti-TSC22D1 antibody (71-120 aa) (STJ96123)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human TSC22D1 at the amino acid range 71-120
General Information
| Short Description | Rabbit polyclonal anti-TSC22 domain family protein 1 (71-120 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TSC22D1 |
| Gene ID | 8848 |
| Uniprot ID | T22D1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human TSC22D1 at the amino acid range 71-120 |
| Immunogen Region | 71-120 aa |
| Specificity | TSC-22 Polyclonal Antibody detects endogenous levels of TSC-22 protein. |
Additional Info
| Function | Transcriptional repressor. Acts on the C-type natriuretic peptide (CNP) promoter. Acts to promote CASP3-mediated apoptosis. Positively regulates TGF-beta signaling by interacting with SMAD7 which inhibits binding of SMAD7 to TGFBR1, preventing recruitment of SMURF ubiquitin ligases to TGFBR1 and inhibiting SMURF-mediated ubiquitination and degradation of TGFBR1. Contributes to enhancement of TGF-beta signaling by binding to and modulating the transcription activator activity of SMAD4. Promotes TGF-beta-induced transcription of COL1A2.via its interaction with TFE3 at E-boxes in the gene proximal promoter. Plays a role in the repression of hematopoietic precursor cell growth. Promotes IL2 deprivation-induced apoptosis in T-lymphocytes, via repression of TSC22D3/GILZ transcription and activation of the caspase cascade. Isoform 1: May act to negatively regulate TGFB3 signaling and thereby inhibit cell death in mammary gland cells. Isoform 2: Positively regulates cell death in response to TGFB3 during mammary gland involution. |
| Protein Name | Tsc22 Domain Family Protein 1Cerebral Protein 2Hucep-2Regulatory Protein Tsc-22Tgfb-Stimulated Clone 22 HomologTransforming Growth Factor Beta-1-Induced Transcript 4 Protein |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusCell MembranePeripheral Membrane ProteinIsoform 1: CytoplasmMitochondrionIsoform 2: CytoplasmIsoform 5: Cytoplasm |
| Alternative Antibody Names | Anti-Tsc22 Domain Family Protein 1 antibodyAnti-Cerebral Protein 2 antibodyAnti-Hucep-2 antibodyAnti-Regulatory Protein Tsc-22 antibodyAnti-Tgfb-Stimulated Clone 22 Homolog antibodyAnti-Transforming Growth Factor Beta-1-Induced Transcript 4 Protein antibodyAnti-TSC22D1 antibodyAnti-KIAA1994 antibodyAnti-TGFB1I4 antibodyAnti-TSC22 antibodyAnti-hucep-2 antibody |
Information sourced from Uniprot.org