| Function | Minor enzyme contributing to the isomerization of uridine to pseudouridine (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs) such as COXI and COXIII mt-mRNAs. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation. Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine(55) from uracil-55, in the psi GC loop of a subset of tRNAs. |
| Protein Name | Pseudouridylate Synthase Trub2 - MitochondrialTrub Pseudouridine Synthase Homolog 2Trna Pseudouridine 55 Synthase Trub2Psi55 Synthase Trub2 |
| Database Links | |
| Cellular Localisation | Mitochondrion MatrixLocalizes To Mitochondrial Rna GranulesPlatforms For Post-Transcriptional Rna Modification And Ribosome Assembly |
| Alternative Antibody Names | Anti-Pseudouridylate Synthase Trub2 - Mitochondrial antibodyAnti-Trub Pseudouridine Synthase Homolog 2 antibodyAnti-Trna Pseudouridine 55 Synthase Trub2 antibodyAnti-Psi55 Synthase Trub2 antibodyAnti-TRUB2 antibody |
Information sourced from Uniprot.org
