Anti-TRPV5 antibody (Cytoplasmic Domain) (STJ13102520)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from the cytoplasmic domain of mouse TRPV5 conjugated to an immunogenic carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-TRPV5 (Cytoplasmic Domain) for use in IHC and WB in Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | Trpv5 |
| Gene ID | 194352 |
| Uniprot ID | TRPV5_MOUSE |
| Immunogen | A synthetic peptide from the cytoplasmic domain of mouse TRPV5 conjugated to an immunogenic carrier protein was used as the antigen. |
| Immunogen Region | Cytoplasmic Domain |
| Specificity | Specific for TRPV5. |
Additional Info
| Post Translational Modifications | Glycosylated. |
| Function | Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating. |
| Protein Name | Transient Receptor Potential Cation Channel Subfamily V Member 5Trpv5Calcium Transport Protein 2Cat2Epithelial Calcium Channel 1Ecac1Osm-9-Like Trp Channel 3Otrpc3 |
| Database Links | Reactome: R-MMU-3295583 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinColocalized With S100a10 And Anax2 Along The Apical Domain Of Kidney Distal Tubular Cells |
| Alternative Antibody Names | Anti-Transient Receptor Potential Cation Channel Subfamily V Member 5 antibodyAnti-Trpv5 antibodyAnti-Calcium Transport Protein 2 antibodyAnti-Cat2 antibodyAnti-Epithelial Calcium Channel 1 antibodyAnti-Ecac1 antibodyAnti-Osm-9-Like Trp Channel 3 antibodyAnti-Otrpc3 antibodyAnti-Trpv5 antibody |
Information sourced from Uniprot.org