| Host: |
Rabbit |
| Applications: |
IHC-P |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-TRPS1 (C-Term) is suitable for use in Immunohistochemistry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
ZR382 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Tris-HCI buffer containing stabilizing protein (BSA) and <0.1% ProClin |
| Purification: |
Affinity purified |
| Dilution Range: |
1:100-200 |
| Storage Instruction: |
Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C. |
| Gene Symbol: |
TRPS1 |
| Gene ID: |
7227 |
| Uniprot ID: |
TRPS1_HUMAN |
| Immunogen Region: |
C-Term |
| Specificity: |
Positive Control: Normal breast or breast carcinoma |
| Immunogen: |
Synthesized peptide corresponding to the C-terminus of human TRPS1 protein |
| Tissue Specificity | Ubiquitously expressed in the adult. Found in fetal brain, lung, kidney, liver, spleen and thymus. More highly expressed in androgen-dependent than in androgen-independent prostate cancer cells. |
| Post Translational Modifications | Sumoylated. Sumoylation in the repressor domain inhibits the transcription repression activity. Sumoylation on Lys-1201 is the major site. Appears to be sumoylated on multiple sites. |
| Function | Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. |
| Protein Name | Zinc Finger Transcription Factor Trps1Tricho-Rhino-Phalangeal Syndrome Type I ProteinZinc Finger Protein Gc79 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Zinc Finger Transcription Factor Trps1 antibodyAnti-Tricho-Rhino-Phalangeal Syndrome Type I Protein antibodyAnti-Zinc Finger Protein Gc79 antibodyAnti-TRPS1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
