Formalin-fixed, paraffin-embedded human breast carcinoma stained with anti-TRPS1 antibody using peroxidase-conjugate and DAB chromogen. Note the nuclear staining of tumor cells

Anti-TRPS1 antibody (C-Term) [ZR382] (STJ180600)

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STJ180600
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Host: Rabbit
Applications: IHC-P
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-TRPS1 (C-Term) is suitable for use in Immunohistochemistry research applications.
Clonality : Monoclonal
Clone ID : ZR382
Conjugation: Unconjugated
Isotype: IgG
Formulation: Tris-HCI buffer containing stabilizing protein (BSA) and <0.1% ProClin
Purification: Affinity purified
Dilution Range: 1:100-200
Storage Instruction: Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C.
Gene Symbol: TRPS1
Gene ID: 7227
Uniprot ID: TRPS1_HUMAN
Immunogen Region: C-Term
Specificity: Positive Control: Normal breast or breast carcinoma
Immunogen: Synthesized peptide corresponding to the C-terminus of human TRPS1 protein
Tissue Specificity Ubiquitously expressed in the adult. Found in fetal brain, lung, kidney, liver, spleen and thymus. More highly expressed in androgen-dependent than in androgen-independent prostate cancer cells.
Post Translational Modifications Sumoylated. Sumoylation in the repressor domain inhibits the transcription repression activity. Sumoylation on Lys-1201 is the major site. Appears to be sumoylated on multiple sites.
Function Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes.
Protein Name Zinc Finger Transcription Factor Trps1
Tricho-Rhino-Phalangeal Syndrome Type I Protein
Zinc Finger Protein Gc79
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Zinc Finger Transcription Factor Trps1 antibody
Anti-Tricho-Rhino-Phalangeal Syndrome Type I Protein antibody
Anti-Zinc Finger Protein Gc79 antibody
Anti-TRPS1 antibody

Information sourced from Uniprot.org

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