| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TRPS1 (20-260) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:2000-1:10000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TRPS1 |
| Gene ID: |
7227 |
| Uniprot ID: |
TRPS1_HUMAN |
| Immunogen Region: |
20-260 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 20-260 of human TRPS1 (NP_054831.2). |
| Immunogen Sequence: |
PPLRNVASEGEGQILEPIGT ESKVSGKNKEFSADQMSENT DQSDAAELNHKEEHSLHVQD PSSSSKKDLKSAVLSEKAGF NYESPSKGGNFPSFPHDEVT DRNMLAFSSPAAGGVCEPLK SPQRAEADDPQDMACTPSGD SLETKEDQKMSPKATEETGQ AQSGQANCQGLSPVSVASKN PQVPSDGGVRLNKSKTDLLV NDNPDPAPLSPELQDFKCNI CGYGYYGNDPTDLIKHFRK |
| Tissue Specificity | Ubiquitously expressed in the adult. Found in fetal brain, lung, kidney, liver, spleen and thymus. More highly expressed in androgen-dependent than in androgen-independent prostate cancer cells. |
| Post Translational Modifications | Sumoylated. Sumoylation in the repressor domain inhibits the transcription repression activity. Sumoylation on Lys-1201 is the major site. Appears to be sumoylated on multiple sites. |
| Function | Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. |
| Protein Name | Zinc Finger Transcription Factor Trps1Tricho-Rhino-Phalangeal Syndrome Type I ProteinZinc Finger Protein Gc79 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Zinc Finger Transcription Factor Trps1 antibodyAnti-Tricho-Rhino-Phalangeal Syndrome Type I Protein antibodyAnti-Zinc Finger Protein Gc79 antibodyAnti-TRPS1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
