Anti-TRPM8 antibody (Extracellular region) (STJA0005624)

SKU:
STJA0005624-100

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Host: Rabbit
Applications: WB/ICC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-TRPM8 (Extracellular region) is suitable for use in Western Blot and Immunocytochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol
Purification: Antigen Affinity Purified
Dilution Range: WB
IHC
ICC
IP
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TRPM8
Gene ID: 79054
Uniprot ID: TRPM8_HUMAN
Immunogen Region: Extracellular region
Specificity: This antibody detects a 130 kDa* protein on SDS-PAGE immunoblots of human MDA-MB-231 and MCF-7 cells. The antibody is also recommended for immunocytochemical labeling of cells.
Immunogen: TRPM8 synthetic peptide (coupled to carrier) corresponding to amino acids in the extracellular region of human TRPM8. This site is well conserved in rat and mouse TRPM8, but has low homology to other TRPM family members.
Function Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity. Plays a role in prostate cancer cell migration. Isoform 2 and isoform 3 negatively regulate menthol- and cold-induced channel activity by stabilizing the closed state of the channel.
Protein Name Transient Receptor Potential Cation Channel Subfamily M Member 8
Long Transient Receptor Potential Channel 6
Ltrpc-6
Ltrpc6
Transient Receptor Potential P8
Trp-P8
Database Links Reactome: R-HSA-3295583
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Membrane Raft
Endoplasmic Reticulum Membrane
Localizes To Membrane Rafts But Is Also Located In The Cell Membrane Outside Of These Regions Where Channel Response To Cold Is Enhanced Compared To Membrane Rafts
Located In The Endoplasmic Reticulum In Prostate Cancer Cells
Alternative Antibody Names Anti-Transient Receptor Potential Cation Channel Subfamily M Member 8 antibody
Anti-Long Transient Receptor Potential Channel 6 antibody
Anti-Ltrpc-6 antibody
Anti-Ltrpc6 antibody
Anti-Transient Receptor Potential P8 antibody
Anti-Trp-P8 antibody
Anti-TRPM8 antibody
Anti-LTRPC6 antibody
Anti-TRPP8 antibody

Information sourced from Uniprot.org

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