Anti-TRPM4 antibody (STJ13100427)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from mouse TRPM4 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat.
General Information
| Short Description | Rabbit polyclonal anti-TRPM4 for use in IHC and WB in Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1:500 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20ยฐC for long term storage and refrigerated at 2-8ยฐC for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | Trpm4 |
| Gene ID | 68667 |
| Uniprot ID | TRPM4_MOUSE |
| Immunogen | A synthetic peptide from mouse TRPM4 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat. |
| Specificity | Specific for TRPM4. |
Additional Info
| Post Translational Modifications | Phosphorylation by PKC leads to increase the sensitivity to Ca(2+). Sumoylated. Desumoylated by SENP1. |
| Function | Calcium-activated selective cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway. Essential for the migration but not the maturation of dendritic cells. Plays a role in keratinocyte differentiation. Isoform 3: Lacks channel activity. |
| Protein Name | Transient Receptor Potential Cation Channel Subfamily M Member 4Calcium-Activated Non-Selective Cation Channel 1Long Transient Receptor Potential Channel 4Ltrpc-4Ltrpc4 |
| Database Links | Reactome: R-MMU-3295583 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEndoplasmic ReticulumGolgi Apparatus |
| Alternative Antibody Names | Anti-Transient Receptor Potential Cation Channel Subfamily M Member 4 antibodyAnti-Calcium-Activated Non-Selective Cation Channel 1 antibodyAnti-Long Transient Receptor Potential Channel 4 antibodyAnti-Ltrpc-4 antibodyAnti-Ltrpc4 antibodyAnti-Trpm4 antibodyAnti-Ltrpc4 antibody |
Information sourced from Uniprot.org