| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TRPM1 (1350-1400 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
TRPM1 |
| Gene ID: |
4308 |
| Uniprot ID: |
TRPM1_HUMAN |
| Immunogen Region: |
1350-1400 aa |
| Specificity: |
Specific for TRPM1. |
| Immunogen: |
A synthetic peptide from aa region 1300-1400 of human TRPM1 conjugated to blue carrier protein was used as the antigen. |
| Function | Constitutively open nonselective divalent cation-conducting channels which mediate the influx of Ca(2+), Mg(2+), Mn(2+), Ba(2+), and Ni(2+) into the cytoplasm, leading to membrane depolarization. Impermeable to zinc ions. In addition, forms heteromultimeric ion channels with TRPM3 which are permeable for calcium and zinc ions. Plays an essential role for the depolarizing photoresponse of retinal ON bipolar cells. In the dark, tonic release of glutamate activates the G-protein coupled receptor for glutamate, GRM6, its activation induces the release of G(o) protein and the beta-gamma G protein dimer. Both subunits can interact and inactivate the TRPM1 channel. A light onset, induces decrease in glutamate release and deactivation of GRM6 leading to channel opening and membrane depolarization. May play a role in metastasis suppression. |
| Protein Name | Transient Receptor Potential Cation Channel Subfamily M Member 1Long Transient Receptor Potential Channel 1Ltrpc1Melastatin-1 |
| Database Links | Reactome: R-HSA-3295583Reactome: R-HSA-9824594 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum MembraneCell ProjectionAxonIn On-Bipolar Cells Is Intracellular And Located Predominantly In The ErAnd Not At The Plasma Membrane Or Golgi Apparatus |
| Alternative Antibody Names | Anti-Transient Receptor Potential Cation Channel Subfamily M Member 1 antibodyAnti-Long Transient Receptor Potential Channel 1 antibodyAnti-Ltrpc1 antibodyAnti-Melastatin-1 antibodyAnti-TRPM1 antibodyAnti-LTRPC1 antibodyAnti-MLSN antibodyAnti-MLSN1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
