| Host: | Goat |
| Applications: | Pep-ELISA/IHC |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-Trpc6-Mouse (Internal) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:64000.WB: Preliminary experiments gave an approx 75kDa band in Mouse and Rat Brain and Spinal Cord lysates after 0.3µg/ml antibody staining. Please note that currently we cannot find an explanat |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Immunogen Region: | Internal |
| Accession Number: | NP_038866.2 |
| Immunogen Sequence: | KQSSTRSSEDYHLNS |
| Post Translational Modifications | Phosphorylated by FYN, leading to an increase of TRPC6 channel activity. N-glycosylated. |
| Function | Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion. |
| Protein Name | Short Transient Receptor Potential Channel 6Trpc6Calcium Entry ChannelTransient Receptor Protein 6Trp-6 |
| Database Links | Reactome: R-MMU-114508Reactome: -MMU-139853Reactome: -MMU-3295583 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Short Transient Receptor Potential Channel 6 antibodyAnti-Trpc6 antibodyAnti-Calcium Entry Channel antibodyAnti-Transient Receptor Protein 6 antibodyAnti-Trp-6 antibodyAnti-Trpc6 antibodyAnti-Trp6 antibodyAnti-Trrp6 antibody |
Information sourced from Uniprot.org