Anti-TRPC4AP antibody (C-Term) (STJ13100418)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from the c-terminal region of human TRPC4AP (TRUSS) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat and mouse.
General Information
| Short Description | Rabbit polyclonal anti-TRPC4AP (C-Term) for use in IHC and WB in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20ยฐC for long term storage and refrigerated at 2-8ยฐC for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | TRPC4AP |
| Gene ID | 26133 |
| Uniprot ID | TP4AP_HUMAN |
| Immunogen | A synthetic peptide from the c-terminal region of human TRPC4AP (TRUSS) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat and mouse. |
| Immunogen Region | C-Term |
| Specificity | Specific for TRPC4AP. |
Additional Info
| Function | Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. The DCX(TRPC4AP) complex specifically mediates the polyubiquitination and subsequent degradation of MYC as part of the DesCEND (destruction via C-end degrons) pathway. The DesCEND (destruction via C-end degrons) pathway recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The DCX(TRPC4AP) complex specifically recognizes proteins with an arginine at the minus 3 position (R-3 motif) at the C-terminus, such as MYC, leading to their ubiquitination and degradation. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome. Involved in JNK activation via its interaction with TRAF2. Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1. |
| Protein Name | Short Transient Receptor Potential Channel 4-Associated ProteinTrp4-Associated ProteinTrpc4-Associated ProteinProtein Tap1Tnf-Receptor Ubiquitous Scaffolding/Signaling ProteinProtein Truss |
| Database Links | Reactome: R-HSA-3295583 |
| Cellular Localisation | CytoplasmPerinuclear Region |
| Alternative Antibody Names | Anti-Short Transient Receptor Potential Channel 4-Associated Protein antibodyAnti-Trp4-Associated Protein antibodyAnti-Trpc4-Associated Protein antibodyAnti-Protein Tap1 antibodyAnti-Tnf-Receptor Ubiquitous Scaffolding/Signaling Protein antibodyAnti-Protein Truss antibodyAnti-TRPC4AP antibodyAnti-C20orf188 antibodyAnti-TRRP4AP antibody |
Information sourced from Uniprot.org