| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TRPC1 (400-500) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TRPC1 |
| Gene ID: |
7220 |
| Uniprot ID: |
TRPC1_HUMAN |
| Immunogen Region: |
400-500 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 400-500 of human TRPC1 (NP_001238774.1). |
| Immunogen Sequence: |
LLNLYSLVYNEDKKNTMGPA LERIDYLLILWIIGMIWSDI KRLWYEGLEDFLEESRNQLS FVMNSLYLATFALKVVAHNK FHDFADRKDWDAFHPTLVAE G |
| Tissue Specificity | Seems to be ubiquitous. |
| Post Translational Modifications | Activation of PRKCA induces phosphorylation of TRPC1 and subsequent Ca2+ entry into cells. |
| Function | Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. |
| Protein Name | Short Transient Receptor Potential Channel 1Trpc1Transient Receptor Protein 1Trp-1 |
| Database Links | Reactome: R-HSA-3295583Reactome: R-HSA-418890Reactome: R-HSA-5578775Reactome: R-HSA-983695 |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Short Transient Receptor Potential Channel 1 antibodyAnti-Trpc1 antibodyAnti-Transient Receptor Protein 1 antibodyAnti-Trp-1 antibodyAnti-TRPC1 antibodyAnti-TRP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
