Western blot analysis of extracts of various cell lines, using TRPC1 antibody (STJ114399) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.

Anti-TRPC1 antibody (400-500) (STJ114399)

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STJ114399
£112.50 - £524.50
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Covered by St John's Laboratory Guarantee

Host: Rabbit
Applications: WB/IHC-P/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
IHC-P:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TRPC1
Gene ID: 7220
Uniprot ID: TRPC1_HUMAN
Immunogen Region: 400-500
Specificity: A synthetic peptide corresponding to a sequence within amino acids 400-500 of human TRPC1 (NP_001238774.1).
Immunogen Sequence: LLNLYSLVYNEDKKNTMGPA LERIDYLLILWIIGMIWSDI KRLWYEGLEDFLEESRNQLS FVMNSLYLATFALKVVAHNK FHDFADRKDWDAFHPTLVAE G
Tissue Specificity Seems to be ubiquitous.
Post Translational Modifications Activation of PRKCA induces phosphorylation of TRPC1 and subsequent Ca2+ entry into cells.
Function Forms a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Also activated by intracellular calcium store depletion. Isoform Short: Forms a receptor-activated non-selective calcium permeant cation channel. Also activated by intracellular calcium store depletion.
Protein Name Short Transient Receptor Potential Channel 1
Trpc1
Transient Receptor Protein 1
Trp-1
Database Links Reactome: R-HSA-3295583
Reactome: R-HSA-418890
Reactome: R-HSA-5578775
Reactome: R-HSA-983695
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Short Transient Receptor Potential Channel 1 antibody
Anti-Trpc1 antibody
Anti-Transient Receptor Protein 1 antibody
Anti-Trp-1 antibody
Anti-TRPC1 antibody
Anti-TRP1 antibody

Information sourced from Uniprot.org

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