| Host: | Mouse |
| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
| Short Description : | Mouse monoclonal antibody anti-Triple Functional Domain Protein is suitable for use in ELISA research applications. |
| Clonality : | Monoclonal |
| Clone ID : | SAA1532 |
| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Formulation: | 0.01M PBS |
| Purification: | Protein A/G purified from cell culture supernatant |
| Concentration: | 1 mg/mL |
| Storage Instruction: | Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months |
| Gene Symbol: | TRIO |
| Gene ID: | 7204 |
| Uniprot ID: | TRIO_HUMAN |
| Post Translational Modifications | Phosphorylated on serine residue(s). |
| Function | Guanine nucleotide exchange factor (GEF) for RHOA and RAC1 GTPases. Involved in coordinating actin remodeling, which is necessary for cell migration and growth. Plays a key role in the regulation of neurite outgrowth and lamellipodia formation. In developing hippocampal neurons, limits dendrite formation, without affecting the establishment of axon polarity. Once dendrites are formed, involved in the control of synaptic function by regulating the endocytosis of AMPA-selective glutamate receptors (AMPARs) at CA1 excitatory synapses. May act as a regulator of adipogenesis. |
| Protein Name | Triple Functional Domain ProteinPtprf-Interacting Protein |
| Database Links | Reactome: R-HSA-193648Reactome: R-HSA-416476Reactome: R-HSA-416482Reactome: R-HSA-418885Reactome: R-HSA-8980692Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013408Reactome: R-HSA-9013409Reactome: R-HSA-9013423 |
| Cellular Localisation | CytoplasmCell Projection |
| Alternative Antibody Names | Anti-Triple Functional Domain Protein antibodyAnti-Ptprf-Interacting Protein antibodyAnti-TRIO antibody |
Information sourced from Uniprot.org
