| Host: | Rabbit |
| Applications: | IHC/WB |
| Reactivity: | Mouse/Rat/Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal anti-TRIM9 (Internal Region) for use in IHC and WB in Mouse, Rat and Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Lyophilised |
| Purification: | IgG purified |
| Dilution Range: | IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | Trim9 |
| Gene ID: | 94090 |
| Uniprot ID: | TRIM9_MOUSE |
| Immunogen Region: | Internal Region |
| Specificity: | Specific for TRIM9. |
| Immunogen: | A synthetic peptide from internal region of mouse TRIM9 conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in human and rat. |
| Post Translational Modifications | Auto-ubiquitinated. |
| Function | E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation. |
| Protein Name | E3 Ubiquitin-Protein Ligase Trim9Ring-Type E3 Ubiquitin Transferase Trim9Tripartite Motif-Containing Protein 9 |
| Database Links | Reactome: R-MMU-983168 |
| Cellular Localisation | CytoplasmCell ProjectionDendriteCytoplasmic VesicleSecretory VesicleSynaptic VesicleSynapseCytoskeletonEnriched At Synaptic Terminals Where It Exists In A Soluble Form And A Synaptic Vesicle-Associated FormAssociated With The CytoskeletonFound In Proximal Dendrites Of Pyramidal Neurons In The Cerebral Cortex And HippocampusAnd Purkinje Cells In The Cerebellum |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Trim9 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Trim9 antibodyAnti-Tripartite Motif-Containing Protein 9 antibodyAnti-Trim9 antibodyAnti-Kiaa0282 antibody |
Information sourced from Uniprot.org